Chronic excitotoxic lesion of the dorsal raphe nucleus induces sodium appetite
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چکیده
منابع مشابه
Chronic excitotoxic lesion of the dorsal raphe nucleus induces sodium appetite.
We determined if the dorsal raphe nucleus (DRN) exerts tonic control of basal and stimulated sodium and water intake. Male Wistar rats weighing 300-350 g were microinjected with phosphate buffer (PB-DRN, N = 11) or 1 microg/0.2 microl, in a single dose, ibotenic acid (IBO-DRN, N = 9 to 10) through a guide cannula into the DRN and were observed for 21 days in order to measure basal sodium appeti...
متن کاملEffect of electrolytic lesion of the dorsal raphe nucleus on water intake and sodium appetite.
The present study determined the effect of an electrolytic lesion of the dorsal raphe nucleus (DRN) on water intake and sodium appetite. Male Wistar rats weighing 290-320 g with a lesion of the DRN (L-DRN), performed two days before experiments and confirmed by histology at the end of the experiments, presented increased sensitivity to the dehydration induced by fluid deprivation. The cumulativ...
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Introduction: The role of serotonergic fibers in avoidance learning is controversial. Involvement of the dorsal raphe nucleus (DRN), the main source of hippocampal projecting serotonergic fibers in acquisition, consolidation and retrieval of passive avoidance (PA) learning, was investigated by functional suppression of this area. Materials and Methods: DRN functional inactivation was done by li...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 2005
ISSN: 0100-879X
DOI: 10.1590/s0100-879x2005001100015